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Soneta (Tizanidine) 2mg, 10 Ct - ATCO Pack Size:10 Tablets Skin rash and frequent coldsTizanidine is a centrally acting skeletal muscle relaxant. Its principal site of action is the spinal cord, where the evidence suggests that, by stimulating presynaptic alpha2 receptors, it inhibits the release of excitatory aminoacids that simulate N methyl D aspartate (NMDA) receptors. Polysynaptic signal transmission at spinal interneuron level, which is responsible for excessive muscle tone, is thus inhibited and muscle tone reduced. Composition